Runes can be cast directly on a monster's current location, and will detonate at once. The next monster or player to walk over the rune will trigger it, and the appropriate spell will cast from the spot of the rune. Clicking on the dungeon floor will set the rune, so long as the cursor is within the character's line of sight. To set a rune, place it in the belt, then click the appropriate key: your cursor will become a pointer. They deal Fire or Lightning Damage, or cast a Stone Curse, on monsters that walk over the activated rune. Runes are dropped by chests and monsters and randomly sold by Adria the Witch.

Runes are trap-like objects that can only be found in the Hellfire expansion.

Their role changed again in Diablo III, where they are no longer items, but affect the way skills work. They were reintroduced in Diablo 2: Lord of Destruction as a new type of socketable item along with jewels. They made their first appearance in the Diablo expansion Hellfire as usable items.

Runes are magical symbols carved on rock.

Diablo 2 wiki dol rune